DESCRIPTION
Tri-En-All 400 by Douglas Laboratories® contains 400 I.U. of 100% natural-source, unesterified vitamin E (dalpha-tocopherol),
as well as a guaranteed minimum of the d-beta, d-gamma and d-delta tocopherols, which is
unique among most mixed tocopherol products available. In addition, 25 mg of palm derived mixed
tocotrienols are included in Tri-En-All 400. No synthetic vitamin E is used.
FUNCTIONS
Vitamin E is one of the body’s most important antioxidant nutrients. Antioxidants protect healthy cells from
oxidative and free radical damage. Free radicals are unstable chemicals formed in the body during
metabolism and from exposure to environmental sources, such as pollution and cigarette smoke. Free
radicals are necessary for energy metabolism and immune function, but when an excessive number of free
radicals are formed, they can attack healthy cells, especially cell membrane lipids and proteins. This, in turn,
is thought to contribute to a number of degenerative diseases.
Vitamin E is an especially valuable antioxidant in the cell membranes, where it prevents oxidation of
unsaturated fatty acids by trapping free radicals. This helps stabilize and protect cell membranes, especially
red blood cells and tissues sensitive to oxidation, such as the lungs, eyes, and arteries. Vitamin E also
protects the liver and other tissues from the free-radical damage of toxicants, such as mercury, lead, ozone,
nitrous oxide, carbon tetrachloride, benzene, cresol, and various drugs.
Related to its antioxidant properties, vitamin E is important for normal immune function, and many studies
show that it prevents lipid peroxidation of blood lipoproteins, such as LDL-cholesterol.
While many think that the term “vitamin E” refers to a single entity, it actually describes a family of eight
different compounds known as the tocopherols and the tocotrienols. Both the tocopherols and tocotrienols are
further divided into their alpha, beta, gamma and delta isomers. These two groups of compounds are similar
with respect to their structure, but do have subtle molecular structure differences.
The d-alpha tocopherol isomer is the most well-known form of vitamin E. However, recent scientific evidence
indicates that gamma-tocopherol may possess unique, distinguishable features. This tocopherol is the major
form of vitamin E in seeds and in the US diet, though it has not been studied as broadly as alpha-tocopherol.
Numerous studies have shown gamma-tocopherol to have excellent antioxidant abilities that complement the
antioxidant ability of alpha-tocopherol. Additionally, some studies have shown that high dose supplementation
of alpha-tocopherols can deplete both plasma and tissue levels of gamma-tocopherol in the body.
Tocotrienols are found in various foods, but are particularly abundant in rice bran and palm oil. Like
tocopherols, tocotrienols function as powerful antioxidants. In certain systems, there is evidence that
tocotrienols may even possess greater antioxidant activity compared with tocopherols. In addition to their
antioxidant function, tocotrienols have demonstrated the ability to reduce cholesterol synthesis by inhibiting the
hepatic enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase, a rate-limiting enzyme in cholesterol
biosynthesis. This finding has resulted in research investigating the ability of tocotrienols to affect cholesterol
levels as well as other cardiovascular health parameters.
Tri-En-All 400 is different from most mixed tocopherols products because it contains natural mixed tocopherols
with a minimum guaranteed amount of the d-beta, d-gamma and d-delta tocopherols, as well as a significant
amount of natural mixed tocotrienols.
INDICATIONS
Tri-En-All may be a useful dietary supplement for individuals wishing to supplement their diet with all eight
forms of vitamin E.
FORMULA (#98738)
Each Softgel Contains:
Vitamin E....................................................................... 400 IU
(as d-alpha tocopherol)
with mixed tocopherols
providing a minimum of:
Gamma-tocopherol ....................................................... 280 mg
Beta and Delta-tocopherols .......................................... 40 mg
Mixed Tocotrienols (from palm) .................................... 25 mg
SUGGESTED USE
Adults take one softgel daily or as directed by physician.
SIDE EFFECTS
No adverse side effects have been reported.
STORAGE
Store in a cool, dry place, away from direct light. Keep out of reach of children
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